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Electrokinetic-driven Microfluidic System in Poly(dimethylsiloxane) for Mass Spectrometry Detection Integrating Sample Injection, Capillary Electrophoresis, and Electrospray Emitter On-chip by Sara Thorslund; Peter Lindberg; Per E. Andrén; Fredrik Nikolajeff; Jonas Bergquist is a Engineering article available to read on EtoBox.
What is Electrokinetic-driven Microfluidic System in Poly(dimethylsiloxane) for Mass Spectrometry Detection Integrating Sample Injection, Capillary Electrophoresis, and Electrospray Emitter On-chip about?
## Electrokinetic-driven microfluidic system in poly(dimethylsiloxane) for mass spectrometry detection integrating sample injection, capillary electrophoresis, and electrospray emitter on-chip A novel microsystem device in poly(dimethylsiloxane) (PDMS) for MS detection is presented. The microchip integrates sample injection, capillary electrophoretic separation, and electrospray emitter in a single substrate, and all modules are fabricated in the PDMS bulk material. The injection and separation flow is driven electrokinetically and the total amount of external equipment needed consists of a three-channel highvoltage power supply. The instant switching between sample injection and separation is performed through a series of low-cost relays, limiting the separation field strength to a maximum of 270 V/cm. We show that this set-up is sufficient to accomplish electrospray MS analysis and, to a moderate extent, microchip separation of standard peptides. A new method of instant in-channel oxidation makes it possible to overcome the problem of irreversibly bonded PDMS channels that have recovered their hydrophobic properties over time. The fast method turns the channel surfaces hydrophili
Who reads Electrokinetic-driven Microfluidic System in Poly(dimethylsiloxane) for Mass Spectrometry Detection Integrating Sample Injection, Capillary Electrophoresis, and Electrospray Emitter On-chip?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Sara Thorslund; Peter Lindberg; Per E. Andrén; Fredrik Nikolajeff; Jonas Bergquist
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0173-0835)
- Published
- 2005
- Language
- EN
- Field
- Engineering (Physical Sciences)