Can I read Immunization of Naïve Mice with Mouse Laminin-1 Affected Pregnancy Outcome in a Mouse Model on EtoBox?

Immunization of Naïve Mice with Mouse Laminin-1 Affected Pregnancy Outcome in a Mouse Model by Shelly Tartakover Matalon; Miri Blank; Eiji Matsuura; Junko Inagaki; Motoyoshi Nomizu; Yair Levi; Takao Koike; Yaniv Shere; Asher Ornoy; Yehuda Shoenfeld is a scholarly article available to read on EtoBox.

What is Immunization of Naïve Mice with Mouse Laminin-1 Affected Pregnancy Outcome in a Mouse Model about?

**PROBLEM:** Laminins have important roles during placental and embryonic development. The aim of our study was to determine if active immunization of mice with laminin‐1 could elicit an autoimmune response, and induce features of reproductive failure. **METHOD OF STUDY:** BALB/c mice were immunized with mouse laminin‐1. Autoantibodies to laminin‐1 were measured by enzyme‐linked immunosorbent assay. Pregnant mice were killed on day 14 of pregnancy and examined for pregnancy outcome. **RESULTS:** Mice immunized with laminin‐1 developed elevated levels of anti‐laminin‐1 auto‐antibodies contrary to the control group. A higher fetal resorption rate was found in the laminin‐1 immunized group (23.8%) compared with that of the control group (12.2%), and was even higher in the subgroup of those animals with very high levels of anti‐laminin‐1 (__P__ < 0.01). Laminin‐1 immunized mice also had lower fetal and placental weights. **CONCLUSIONS:** Active immunization with laminin‐1 followed by elevated circulating anti‐laminin‐1 antibodies results in reproductive failure manifested by a higher fetal resorption rate.

Author

Shelly Tartakover Matalon; Miri Blank; Eiji Matsuura; Junko Inagaki; Motoyoshi Nomizu; Yair Levi; Takao Koike; Yaniv Shere; Asher Ornoy; Yehuda Shoenfeld

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 8755-8920)

Published

2003

Language

EN