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This study investigates the effect of mixing time on the solubilization of poorly water-soluble drug Carbamazepine in dry granulation using Soluplus as a solubilizer. Results indicate that optimal blend uniformity and drug release were achieved at 6 minutes of mixing, while longer mixing times led to particle segregation and decreased drug solubilization. The findings suggest that careful control of mixing time is crucial for achieving effective drug formulation in high shear granulation processes.

Author
球世多
Language
EN