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Type 2 mixed monoclonal IgM and polyclonal IgG cryoglobulinemia can be associated with concurrent renal and intestinal thrombosis: Case report by Sandeep Kumar; Yazan Al-Othman; Sami Zarouk; Ping L. Zhang; Zhenhong Qu is a Medicine article available to read on EtoBox.

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Three variants of cryoglobulinemic glomerulopathy are well known, however, the concurrent acute enteritis secondary to a mixed polyclonal cryoglobulin associated thrombotic vasculitis is rarely reported in the literature. We report a case of a 72-year-old man with medical history of hypertension, leukocytoclastic vasculitis, positive serum cryoglobulin, hepatitis C, and membranoproliferative pattern of glomerulonephritis diagnosed 4 years ago. This patient recently presented with abdominal pain for one week. Labs showed worsening renal function, monoclonal IgM-kappa, and positive cryoglobulin in his serum, but negative hepatitis C test. The second renal biopsy showed a membranoproliferative pattern of glomerulopathy with many hyaline thrombi in the glomerular capillary loops. A mixed monoclonal IgM and polyclonal IgG cryoglobulinemic glomerulonephritis (type 2) was diagnosed. His concurrent jejunal biopsy revealed infiltration of neutrophils into glands and submucosal thrombus consistent with ischemic acute jejunitis. The submucosal thrombus of the jejunal biopsy was morphologically similar to the hyaline-thrombi found in glomerular capillary loops. Therefore, we concluded that cry

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Author

Sandeep Kumar; Yazan Al-Othman; Sami Zarouk; Ping L. Zhang; Zhenhong Qu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)