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Benzoic-D5 acid as D2 receptor agonist in the treatment of rotenone induced Parkinson’s disease in mice by Syed Awais Ali Zaidi; Mahtab Ahmad Khan; Muhammad Rizwan Khan; Hammad Ahmed; Zaib Ali Shahryar; Muhammad Umar Khayam Sahibzada; Saad Alghamdi; Abdulelah Aljuaid; Mazen Almehmadi; Mamdouh Allahyani is a Chemistry article available to read on EtoBox.

What is Benzoic-D5 acid as D2 receptor agonist in the treatment of rotenone induced Parkinson’s disease in mice about?

Parkinson's disease is a progressive neurological disorder that affects movement. It is caused by the degeneration of dopamine-producing neurons in the brain. There is no cure for Parkinson's disease, but there are treatments available that can help manage the symptoms. Medications such as levodopa, dopamine agonists and Amantadine (Amd) can help to increase dopamine levels in the brain. Sodium benzoate (Benzoic-D5) is used as preservative in foods due to its antimicrobial potential. Benzoic-D5 showed a pivotal role in ameliorating the symptoms of Parkinson's disease (PkD) in animal model. The current study is designed to probe the anti-Parkinson potential of Benzoic-D5 in the rotenone (ROT)-induced PkD mice. Behavioral studies showed improvement in sensory-motor functions, and neuromuscular strength in wire hanging test, grip strength, vertical rod test, and swim test. Evaluation of biochemical markers suggested increase in catalase (CAT) and superoxide dismutase (SOD), but decreases in the malondialdehyde (MDA)

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Author

Syed Awais Ali Zaidi; Mahtab Ahmad Khan; Muhammad Rizwan Khan; Hammad Ahmed; Zaib Ali Shahryar; Muhammad Umar Khayam Sahibzada; Saad Alghamdi; Abdulelah Aljuaid; Mazen Almehmadi; Mamdouh Allahyani

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)