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Restricted Access Magnetic Imprinted Microspheres for Directly Selective Extraction of Tetracycline Veterinary Drugs from Complex Samples by Yanqiang Zhou; Huachun Liu; Jianmin Li; Zhian Sun; Tianpei Cai; Xiaoxiao Wang; Shanwen Zhao; Bolin Gong is a scholarly article available to read on EtoBox.

What is Restricted Access Magnetic Imprinted Microspheres for Directly Selective Extraction of Tetracycline Veterinary Drugs from Complex Samples about?

A novel restricted access media-magnetic molecularly imprinted polymers (RAM-MMIPs) was prepared as magnetic-solid phase extraction (M-SPE) material for tetracyclines (TCs). The RAM-MMIPs can not only specifically adsorb target molecules in samples, but also effectively eliminate the interference of protein macromolecules. The protein exclusion rate is 99.4%. Besides, RAM-MMIPs have a uniform imprinted and hydrophilic layer (600 nm), rapid binding kinetic (35 min), high selectivity and larger adsorption capacity. The M-SPE was coupled with HPLC/UV to extract TCs from untreated milk and egg samples, and several major factors affecting M-SPE efficiency were optimized. Under optimized conditions, the developed method achieved good linearity (R>0.9989), lower limits of detection (LOD) and higher recoveries of TCs. For milk samples, the LOD is 1.03-1.31 μg L and the recovery is 86.7% to 98.6% with relative standard deviation (RSD) of 1.4-5.7%. For the egg samples, the LOD, recovery and RSD are 2.21-2.67 μg L, 84.2-96.5% and 1.7-5.9%, respectively. Consequently, this work provides an improved strategy for the selective extraction and detection of target molecules directly from complex sa

Author

Yanqiang Zhou; Huachun Liu; Jianmin Li; Zhian Sun; Tianpei Cai; Xiaoxiao Wang; Shanwen Zhao; Bolin Gong

Publisher

Elsevier BV

Published

2019

Language

EN