Can I read Interferon-gamma in 5 Patients with Cutaneous Radiation Syndrome After Radiation Therapy on EtoBox?

Interferon-gamma in 5 Patients with Cutaneous Radiation Syndrome After Radiation Therapy by Petra Gottlöber; Marianne Steinert; Wolfgang Bähren; Lutz Weber; Heinz Gerngroß; Ralf Uwe Peter is a scholarly article available to read on EtoBox.

What is Interferon-gamma in 5 Patients with Cutaneous Radiation Syndrome After Radiation Therapy about?

## Background: Irradiation can cause acute inflammatory responses as well as chronic fibrotic alterations of the skin. cutaneous radiation fibrosis evokes a complex of therapeutic problems. however, therapeutic options, apart from surgical approaches, are limited. ## Patients and methods: Five female patients suffering from severe cutaneous fibrosis were treated with interferon-gamma on a low-dose regimen, 3 x 100 microg/week subcutaneously for 6 months, then once per week for another 6 months. in 4 patients, skin thickness was measured with high-frequency (20 mhz) ultrasound in a clinically well-defined target skin lesion. in 1 patient, nuclear magnetic resonance imaging was performed to quantify the extent of cutaneous radiation fibrosis and to monitor the therapeutic outcome. ## Results: All patients suffered from radiation-induced cutaneous fibrosis. additionally, in 1 patient, a fistula, as assessed by lymph vessel scintigraphy, and in another patient a radiation ulcer was diagnosed. in all patients, reduction of radiation-induced fibrosis could be documented. both fistula and radiation ulcer regressed completely under interferon-gamma therapy. ## Conclusion: Low-dose interfer

Author

Petra Gottlöber; Marianne Steinert; Wolfgang Bähren; Lutz Weber; Heinz Gerngroß; Ralf Uwe Peter

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2001

Language

EN