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Spatially Selective Acoustic Pressure Reporting Using Antibubbles by Gomez, Nicolas Moreno; Athanassiadis, Athanasios G.; Reuter, Fabian; Reese, Hendrik; Jade, Helen M.; Poortinga, Albert; Ohl, Claus-Dieter; Fischer, Peer is a scholarly article available to read on EtoBox.

What is Spatially Selective Acoustic Pressure Reporting Using Antibubbles about?

Ultrasound offers promising applications in biology and chemistry, but quantifying local ultrasound conditions remains challenging due to the lack of non-invasive measurement tools. We introduce antibubbles as novel optical reporters of local ultrasound pressure. These liquid-core, air-shell structures encapsulate fluorescent payloads, releasing them upon exposure to low-intensity ultrasound. We demonstrate their versatility by fabricating antibubbles with hydrophilic and hydrophobic payloads, revealing payload-dependent encapsulation efficiency and release dynamics. Using acoustic holograms, we showcase precise spatial control of payload release, enabling visualization of complex ultrasound fields. High-speed fluorescence imaging reveals a gentle, single-shot release mechanism occurring within 20-50 ultrasound cycles. It is thus possible to determine via an optical fluorescence marker what the applied ultrasound pressure was. This work thereby introduces a non-invasive method for mapping ultrasound fields in complex environments, potentially accelerating research in ultrasound-based therapies and processes. The long-term stability and versatility of these antibubble reporters sugg

Author

Gomez, Nicolas Moreno; Athanassiadis, Athanasios G.; Reuter, Fabian; Reese, Hendrik; Jade, Helen M.; Poortinga, Albert; Ohl, Claus-Dieter; Fischer, Peer

Published

2024

Language

EN