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Biocompatible Superparamagnetic Core-shell Nanoparticles for Potential Use in Hyperthermia-enabled Drug Release and as an Enhanced Contrast Agent by Yogita Patil-Sen; Enza Torino; Franca De Sarno; Alfonso Maria Ponsiglione; Vikesh Chhabria; Waqar Ahmed; Tim Mercer is a Materials Science article available to read on EtoBox.
What is Biocompatible Superparamagnetic Core-shell Nanoparticles for Potential Use in Hyperthermia-enabled Drug Release and as an Enhanced Contrast Agent about?
## Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) and core-shell type nanoparticles, consisting of SPIONs coated with mesoporous silica and/or lipid, were synthesised and tested for their potential theranostic applications in drug delivery, magnetic hyperthermia and as a contrast agent. Transmission Electron Microscopy (TEM) confirmed the size of bare and coated SPIONs was in the range of 5–20 nm and 100–200 nm respectively. The superparamagnetic nature of all the prepared nanomaterials as indicated by Vibrating Sample Magnetometry (VSM) and their heating properties under an AC field confirm their potential for hyperthermia applications. Scanning Column Magnetometry (SCM) data showed that extrusion of bare-SPION (b-SPION) dispersions through a 100 nm polycarbonate membrane significantly improved the dispersion stability of the sample. No sedimentation was apparent after 18 h compared to a pre-extrusion estimate of 43% settled at the bottom of the tube over the same time. Lipid coating also enhanced dispersion stability. Transversal relaxation time (T2) measurements for the nanoparticles, using a bench-top relaxometer, displayed a significantly lower value of 46 ms, wi
Who reads Biocompatible Superparamagnetic Core-shell Nanoparticles for Potential Use in Hyperthermia-enabled Drug Release and as an Enhanced Contrast Agent?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Yogita Patil-Sen; Enza Torino; Franca De Sarno; Alfonso Maria Ponsiglione; Vikesh Chhabria; Waqar Ahmed; Tim Mercer
- Publisher
- Institute of Physics; IOP Publishing; Institute of Physics Publishing (ISSN 0957-4484)
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)