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Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome by Alessandra Boncompagni; Jane McNeilly; Mohammed Murtaza; Laura Lucaccioni; Lorenzo Iughetti; Sze Choong Wong; Avril Mason is a Medicine article available to read on EtoBox.

What is Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome about?

Background: Girls with Turner syndrome (TS) are at an increased risk of primary ovarian insufficiency (POI). Good correlation between serum and urinary gonadotrophins exists in children assessed for disorders of puberty, but there is little evidence of their reliability in hypergonadotropic states. Objectives: To determine whether there was a correlation between serum and urinary Luteinising Hormone (uLH) and Follicle-Stimulating Hormone (uFSH) in hypergonadotrophic states, and whether uFSH could suggest an ovarian failure in TS as Anti-Mullerian Hormone (AMH). Patients and Methods: Retrospective cohort study of 37 TS girls attending the paediatric TS clinic in Glasgow between February 2015 and January 2019, in whom 96 non-timed spot urine samples were available with a median age at time of sample of 12.89 years (3.07-20.2 years). uLH and uFSH were measured by chemiluminescent microparticle immunoassay. Simultaneous serum gonadotrophins and AMH were available in 30 and 26 girls, respectively. AMH <4 pmol/L was considered indicative of ovarian failure. Results: A strong correlation was found between serum LH and uLH (r 0.860, P<0.001) and serum FSH and uFSH (r 0.905, p<0.001). Among

Who reads Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome?

Author

Alessandra Boncompagni; Jane McNeilly; Mohammed Murtaza; Laura Lucaccioni; Lorenzo Iughetti; Sze Choong Wong; Avril Mason

Publisher

Walter de Gruyter GmbH

Published

2020

Language

EN

Field

Medicine (Health Sciences)