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The Bacterial Communication System and Its Interference as an Antivirulence Strategy by Suruchi Aggarwal; Pallavi Mahajan; Payal Gupta; Alka Yadav; Gagan Dhawan; Uma Dhawan; Amit Kumar Yadav is a book available to read on EtoBox.

What is The Bacterial Communication System and Its Interference as an Antivirulence Strategy about?

Humans and pathogenic bacteria have been at war since antiquity. The antibiotics aim to kill the pathogen but the intense selection pressure induces the development of antibiotic resistance. The pharmaceutical industry is reluctant to invest further in the development of antibiotics due to their inevitable glum future. Innovative antivirulence therapies that attempt to disarm the pathogens can be a diplomatic way to handle infectious diseases without inciting the development of resistance. Bacteria communicate with each other to bring about density-dependent community behavior, a phenomenon called quorum sensing (QS), which controls virulence, besides other behaviors. Targeting the quorum-sensing system (QSS) to disarm the bacteria is an appealing antivirulence approach since it applies lesser selection pressure to develop resistance. However, the optimal utilization of this strategy in practice requires a deeper understanding of the social dynamics in bacterial communication, ranging from the social network of neighboring bacteria in the community to interconnections of their QS networks that introduce redundancy. Here, we summarize how the bacteria talk—between and beyond species

Author

Suruchi Aggarwal; Pallavi Mahajan; Payal Gupta; Alka Yadav; Gagan Dhawan; Uma Dhawan; Amit Kumar Yadav

Publisher

Elsevier

Published

2023

Language

EN