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Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome by Eva Rial-Pensado; Oscar Freire-Agulleiro; Marcos Ríos; Deng Fu Guo; Cristina Contreras; Patricia Seoane-Collazo; Sulay Tovar; Rubén Nogueiras; Carlos Diéguez; Kamal Rahmouni; Miguel López is a Medicine article available to read on EtoBox.
What is Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome about?
## Objective Bone morphogenetic protein 8B (BMP8B) plays a major role in the regulation of energy homeostasis by modulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. Here, we investigated whether BMP8B's role in metabolism is affected by obesity and the possible molecular mechanisms underlying that action. ## Methods Central treatments with BMP8B were performed in rats fed a standard (SD) and high-fat diet (HFD), as well as in genetically modified mice. Energy balance studies, infrared thermographic analysis of BAT and molecular analysis of the hypothalamus, BAT and WAT were carried out. ## Results We show for the first time that HFD-induced obesity elicits resistance to the central actions of BMP8B on energy balance. This obesity-induced BMP8B resistance is explained by **i)** lack of effects on AMP-activated protein kinase (AMPK) signaling, **ii)** decreased BMP receptors signaling and **iii)** reduced expression of Bardet-Biedl Syndrome 1 (BBS1) protein, a key component of the protein complex BBSome in the ventromedial nucleus of the hypothalamus (VMH). The possible mechanistic involvement of BBS1 in this process is demonstrated by lack of
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- Author
- Eva Rial-Pensado; Oscar Freire-Agulleiro; Marcos Ríos; Deng Fu Guo; Cristina Contreras; Patricia Seoane-Collazo; Sulay Tovar; Rubén Nogueiras; Carlos Diéguez; Kamal Rahmouni; Miguel López
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)