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Predictability of Baroreflex Sensitivity Induced by Phenylephrine Injection via Frequency Domain Indices Computed from Heart Rate and Systolic Blood Pressure Signals During Deep Breathing by Sami Arıca; N. Fırat İnce; Abdi Bozkurt; Ahmet Birand; Ahmed H. Tewfik is a scholarly article available to read on EtoBox.

What is Predictability of Baroreflex Sensitivity Induced by Phenylephrine Injection via Frequency Domain Indices Computed from Heart Rate and Systolic Blood Pressure Signals During Deep Breathing about?

a b s t r a c t Diminished baroreflex sensitivity (BRS) is related to increased risk of sudden cardiac death in myocardial infarction patients and can be used as an indicator for risk level. The BRS is traditionally estimated invasively using vasoactive drugs, such as phenylephrine injection. This method has been widely accepted as a standard in clinical research. Due to its clinical importance, alternative BRS assessment methods have been investigated over the years to eliminate the use of drugs. In this study, the BRS obtained by drug-based (pharmacological) assessment was predicted from a subset of non-pharmacological indices computed from heart rate and systolic pressure signals. In the first phase of a two-phase experimental paradigm, 16 subjects were asked to perform two deep breathings with a 2-min delay in between. In the second phase, the BRS was measured by phenylephrine injection. Indices computed from the first phase describing the spectral and time domain properties of the heart rate and systolic pressure signals were used as predictors to estimate the pharmacological BRS of each subject. In addition to individual spectrum of beat-to-beat interval and systolic blood pr

Author

Sami Arıca; N. Fırat İnce; Abdi Bozkurt; Ahmet Birand; Ahmed H. Tewfik

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1746-8094)

Published

2010

Language

EN