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Nitrogen Insertion in N-Heterocycles by Cam Westphal is a document available to read on EtoBox.
This research presents a method for nitrogen-atom insertion into nitrogen-containing heterocycles using sulfenylnitrenes, specifically precursors SNP-1, SNP-2, and SNP-3, which are stable and allow for reactions without additives over a wide temperature range. The method enhances the chemical diversity of drug discovery libraries by transforming pyrroles, indoles, and imidazoles into more complex structures like pyrimidines and quinazolines. The study demonstrates the effectiveness of this approach through
- Author
- Cam Westphal
- Language
- EN