Can I read Experience of Early-life Pain in Premature Infants Is Associated with Atypical Cerebellar Development and Later Neurodevelopmental Deficits on EtoBox?

Experience of Early-life Pain in Premature Infants Is Associated with Atypical Cerebellar Development and Later Neurodevelopmental Deficits by Kevin M. Cook; Josepheen De Asis-Cruz; Jung-Hoon Kim; Sudeepta K. Basu; Nickie Andescavage; Jonathan Murnick; Emma Spoehr; Melissa Liggett; Adré J. du Plessis; Catherine Limperopoulos is a Medicine article available to read on EtoBox.

What is Experience of Early-life Pain in Premature Infants Is Associated with Atypical Cerebellar Development and Later Neurodevelopmental Deficits about?

## Background Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to earlier-than-typical exposure to the extrauterine environment, and its bright lights, loud noises, and exposures to painful procedures. Given the relative underdeveloped pain modulatory responses in these infants, frequent pain exposures may confer risk for later deficits. ## Methods Resting-state fMRI scans were collected at term equivalent age from 148 (45% male) infants born V/EPT and 99 infants (56% male) born at term age. Functional connectivity analyses were performed between functional regions correlating connectivity to the number of painful skin break procedures in the NICU, including heel lances, venipunctures, and IV placements. Subsequently, preterm infants returned at 18 months, for neurodevelopmental follow-up and completed assessments for autism risk and general neurodevelopment. ## Results We observed that V/EPT infants exhibit pronounced hyperconnectivity within the cerebellum and between the cerebellum and both limbic and paralimbic regions correl

Who reads Experience of Early-life Pain in Premature Infants Is Associated with Atypical Cerebellar Development and Later Neurodevelopmental Deficits?

Author

Kevin M. Cook; Josepheen De Asis-Cruz; Jung-Hoon Kim; Sudeepta K. Basu; Nickie Andescavage; Jonathan Murnick; Emma Spoehr; Melissa Liggett; Adré J. du Plessis; Catherine Limperopoulos

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)