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Optimal Combination Therapy with Tropisetron in 445 Patients with Incomplete Control of Chemotherapy-induced Nausea and Vomiting. by F Hulstaert; S Van Belle; H Bleiberg; J L Canon; M Dewitte; M Buyse; P De Keyser; K J Westelinck is a Medicine article available to read on EtoBox.

What is Optimal Combination Therapy with Tropisetron in 445 Patients with Incomplete Control of Chemotherapy-induced Nausea and Vomiting. about?

## PURPOSE This study evaluated tropisetron (Navoban; Sandoz Pharma, Basle, Switzerland)-based combination therapy in patients who had incomplete control of chemotherapy-induced nausea or vomiting when using tropisetron as a single antiemetic agent. ## PATIENTS AND METHODS One thousand seventy-two patients, who were scheduled to receive at least two identical cycles of emetogenic chemotherapy, were treated with 5 mg tropisetron once daily in their first chemotherapy course. A 2 x 2 x 2 factorial design was used to evaluate three additional treatments to the recommended 5 mg once daily (intravenously [i.v.] on day 1; orally on days 2 through 6) tropisetron regimen during course 2 in those patients who had shown incomplete control of nausea and/or vomiting on any day of course 1. Four hundred forty-five patients were centrally randomized to receive, in addition, open-label dexamethasone (day 1, 0.2 mg/kg i.v.; days 2 through 6, 8 mg orally) and/or open-label alizapride (day 1, 100 mg i.v. and 4 x 50 mg orally; days 2 through 6, 4 x 50 mg orally) and/or double-blind tropisetron (ie, doubling the dose to 10 mg once daily) or corresponding placebo. ## RESULTS Complete response rates (no

Who reads Optimal Combination Therapy with Tropisetron in 445 Patients with Incomplete Control of Chemotherapy-induced Nausea and Vomiting.?

Author

F Hulstaert; S Van Belle; H Bleiberg; J L Canon; M Dewitte; M Buyse; P De Keyser; K J Westelinck

Publisher

American Society of Clinical Oncology; American Society of Clinical Oncology (ASCO) (ISSN 0732-183X)

Published

1994

Language

EN

Field

Medicine (Health Sciences)