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Anti-inflammatory effect of HGF responses to oral traumatic ulcers using an HGF-Tg mouse model by Xinhong Wang; Liting Yan; Yinghua Tang; Xiaoxi He; Xiaomin Zhao; Weijia Liu; Zhicong Wu; Gang Luo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Hepatocyte growth factor (HGF) has been implicated in inhibiting diverse types of inflammation. Oral traumatic ulceration (OTU) is a common disease of the oral mucosa, and inflammation is the main process for ulcer healing. This study aimed to explore the expression of HGF in oral ulcers and its role in ulcer inflammation. The saliva of 14 recurrent alphous stomatitis (RAS) patients, 18 OTU patients and 17 healthy controls was collected. Traumatic ulcers of the left mucosa were observed in 42 wild-type (WT) and 42 HGF-overexpressing transgenic (HGF-Tg) mice. Histological scores, inflammatory cell expression and serum cytokine expression were measured and analyzed on the 5th day. The HGF protein level in ulcer-affected human saliva was 9.3-fold higher than that in healthy saliva. The HGF protein levels in RAS and OTU saliva were 14- and 5.7-fold higher, respectively, than those in healthy saliva. Traumatic ulcers enhanced HGF expression in ulcer-affected oral mucosa and in the blood of C57BL/6 mice by 1.21- and 1.40-fold, respectively. In HGF-Tg mouse traumatic ulcers, HGF expression was 1.34-fold higher than that in wild-type mice. HGF-Tg mice had lower weight loss, less ulcer area

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Author

Xinhong Wang; Liting Yan; Yinghua Tang; Xiaoxi He; Xiaomin Zhao; Weijia Liu; Zhicong Wu; Gang Luo

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)