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Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish ( Danio rerio ) by N. Hinfray; O. Palluel; C. Turies; C. Cousin; J. M. Porcher; F. Brion is a Environmental Science article available to read on EtoBox.
What is Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish ( Danio rerio ) about?
## Abstract Many chemicals in the aquatic environment are able to adversely affect __in vitro__ brain and ovarian aromatase expression/activity. However, it remains to be determined if these substances elicit __in vivo__ effect in fish. With the view to further understanding possible effects of endocrine disrupting chemicals (EDCs) on aromatase function, we first developed methods to measure brain and ovarian aromatase expression/activity in a model species, the zebrafish, and assessed the effect of estradiol (E2) and androstatrienedione (ATD), a steroidal aromatase inhibitor. We showed that __CYP19b__ gene was predominantly expressed in the brain whereas in the ovary __CYP19a__ mRNA level was predominant. Moreover, aromatase activities (AA) were higher in brain than in ovary. In adult zebrafish, E2 treatment had no effect on aromatase expression/activity in brain, whereas at larval stage, E2 strongly triggered __CYP19b__ expression. In the ovaries, E2 led to a complete inhibition of both __CYP19a__ expression and AA. Exposure to ATD led to a total inhibition of both brain and ovarian AA but had no effect on __CYP19__ transcripts abundance. Together, these results provide relevant
Who reads Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish ( Danio rerio )?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- N. Hinfray; O. Palluel; C. Turies; C. Cousin; J. M. Porcher; F. Brion
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)
- Published
- 2006
- Language
- EN
- Field
- Environmental Science (Physical Sciences)