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Variation in Immunoreactive Trypsinogen Concentrations Among Michigan Newborns and Implications for Cystic Fibrosis Newborn Screening by Steven J. Korzeniewski; William I. Young; Harry C. Hawkins; Kevin Cavanagh; Samya Z. Nasr; Carrie Langbo; Kelly R. TenEyck; Scott D. Grosse; Mary Kleyn; Violanda Grigorescu is a Medicine article available to read on EtoBox.
What is Variation in Immunoreactive Trypsinogen Concentrations Among Michigan Newborns and Implications for Cystic Fibrosis Newborn Screening about?
## Abstract ## Objective To investigate variation in immunoreactive trypsinogen (IRT) concentrations by race, sex, birth weight, and gestational age and their implications for the use of percentile‐based cutoffs for cystic fibrosis (CF) newborn screening (NBS) programs. ## Patients and Methods This cross‐sectional population‐based study of resident infants screened in Michigan investigates associations between demographic and perinatal variables and IRT concentrations after controlling for covariates. This study also analyzed how 96th and 99.8th IRT concentration percentiles values calculated by Michigan NBS vary by demographic and perinatal factors. Characteristics of infants having high (≥99.8th percentile) IRT concentrations and negative DNA tests are also explored. ## Results IRT mean concentrations and percentiles vary significantly by race, birth weight, gestational age, and to a lesser degree by sex. The greatest variation in mean IRT concentrations was observed among racial categories; black infants had an adjusted mean concentration of 36 ng/ml and Asian/Pacific Islander infants had a mean concentration of 25 ng/ml compared to an average concentration of 28 ng/ml in white
Who reads Variation in Immunoreactive Trypsinogen Concentrations Among Michigan Newborns and Implications for Cystic Fibrosis Newborn Screening?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Steven J. Korzeniewski; William I. Young; Harry C. Hawkins; Kevin Cavanagh; Samya Z. Nasr; Carrie Langbo; Kelly R. TenEyck; Scott D. Grosse; Mary Kleyn; Violanda Grigorescu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)