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The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy by Nursel Muratoglu Sahin; Havva Nur Peltek Kendirci; Semra Çetinkaya; Şenay Savaş Erdeve; Zehra Aycan is a scholarly article available to read on EtoBox.

What is The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy about?

Background: Some studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results. Methods: Forty-four girls treated with gonadotropinreleasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment. Results: IGF-1 and IGF-1 standard deviation score (SDS) according to chronological age (CA-IGF-1 SDS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p < 0.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between ΔIGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p < 0.05). There was no correlation between GV and IGF-1, ΔIGF-1. GV was negatively correlated with basal LH level at diagnosis (p = 0.008, r = -0.397). Peak LH levels of the patients who had GV-SDS 0 af

Author

Nursel Muratoglu Sahin; Havva Nur Peltek Kendirci; Semra Çetinkaya; Şenay Savaş Erdeve; Zehra Aycan

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN