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Toxicity and Patterns of Failure of Adaptive/Ablative Proton Therapy for Early-Stage, Medically Inoperable Non–Small Cell Lung Cancer by Joe Y. Chang; Ritsuko Komaki; Hong Y. Wen; Beth De Gracia; Jaques B. Bluett; Mary F. McAleer; Stephen G. Swisher; Michael Gillin; Radhe Mohan; James D. Cox is a Medicine article available to read on EtoBox.

What is Toxicity and Patterns of Failure of Adaptive/Ablative Proton Therapy for Early-Stage, Medically Inoperable Non–Small Cell Lung Cancer about?

Purpose: To analyze the toxicity and patterns of failure of proton therapy given in ablative doses for medically inoperable early-stage non-small cell lung cancer (NSCLC). Methods and Materials: Eighteen patients with medically inoperable T1N0M0 (central location) or T2-3N0M0 (any location) NSCLC were treated with proton therapy at 87.5 Gy (relative biological effectiveness) at 2.5 Gy /fraction in this Phase I/II study. All patients underwent treatment simulation with four-dimensional CT; internal gross tumor volumes were delineated on maximal intensity projection images and modified by visual verification of the target volume in 10 breathing phases. The internal gross tumor volumes with maximal intensity projection density was used to design compensators and apertures to account for tumor motion. Therapy consisted of passively scattered protons. All patients underwent repeat four-dimensional CT simulations during treatment to assess the need for adaptive replanning. Results: At a median follow-up time of 16.3 months (range, 4.8-36.3 months), no patient had experienced Grade 4 or 5 toxicity. The most common adverse effect was dermatitis (Grade 2, 67%; Grade 3, 17%), followed by Gra

Who reads Toxicity and Patterns of Failure of Adaptive/Ablative Proton Therapy for Early-Stage, Medically Inoperable Non–Small Cell Lung Cancer?

Author

Joe Y. Chang; Ritsuko Komaki; Hong Y. Wen; Beth De Gracia; Jaques B. Bluett; Mary F. McAleer; Stephen G. Swisher; Michael Gillin; Radhe Mohan; James D. Cox

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2011

Language

EN

Field

Medicine (Health Sciences)