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Umbilical Cord and Maternal Blood Leptin Concentrations in Intrauterine Growth Retardation by Leyla Yildiz; Bahattin Avci; Metin Ingeç is a scholarly article available to read on EtoBox.

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Leptin, the ob gene product, plays an important role in the regulation of body fat mass and weight. In previous studies, it was demonstrated that leptin is detectable in human fetal cord blood as early as at 18 weeks of gestation and that serum leptin concentrations are significantly reduced in small gestational age newborns. In the present study, we investigated whether umbilical and maternal serum leptin concentrations correlate with intrauterine growth retardation (IUGR). In addition, we aimed to determine the relationships between leptin concentration in the maternal and cord blood. We studied 40 newborn infants (21 female and 19 male; gestational age, 38 -42 weeks) and their mothers. Of the infants studied, 10 had IUGR. Serum leptin concentrations were measured by radioimmunoassay. All newborns had detectable leptin concentrations. Leptin concentrations were significantly lower in newborns with IUGR and in their mothers (n= 10; 3.53 ± 1.42 ng/ml, 6.75 ± 1.47 ng/ml, respectively) than in infants experiencing normal growth and their mothers (n= 30; 5.58 ± 2.98 ng/ml, 9.85 ± 6.50 ng/ml, respectively) (p< 0.01 for newborns, p< 0.05 for mothers). There was no significant correlatio

Author

Leyla Yildiz; Bahattin Avci; Metin Ingeç

Publisher

Walter de Gruyter GmbH

Published

2002

Language

EN