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CSF and serum total-tau and phospho-tau(181P) in MS patients by Jacek Jaworski; Marek Psujek; Halina Bartosik-Psujek is a Medicine article available to read on EtoBox.

What is CSF and serum total-tau and phospho-tau(181P) in MS patients about?

In search of biological marker in multiple sclerosis (MS), total-tau and phospho-tau (Thr181) concentrations were established in CSF and serum of 78 patients with MS, using commercially available kits. Serum and CSF concentrations of IgG, IgM, and albumin were assayed simultaneously to calculate quotients and indices of intrathecal synthesis. Serum t-tau detection was strikingly low (23.1%); therefore, this factor was excluded from further analysis. Serum p-tau levels did not correlate with any of indices or quotients. Unexpectedly, CSF t-tau and p-tau showed an inverse relation with MSSS and EDSS, which has not been published elsewhere. Our results do not support utility of serum t-tau and p-tau as surrogate markers for MS.

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Author

Jacek Jaworski; Marek Psujek; Halina Bartosik-Psujek

Publisher

Walter de Gruyter GmbH

Published

2011

Language

EN

Field

Medicine (Health Sciences)