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A Systematic Review of the Diagnostic Accuracy of Prostate Specific Antigen by Philip Harvey; Amman Basuita; Deborah Endersby; Ben Curtis; Aphrodite Iacovidou; Mary Walker is a Medicine article available to read on EtoBox.

What is A Systematic Review of the Diagnostic Accuracy of Prostate Specific Antigen about?

## Background: Prostate cancer is the fourth commonest cancer in the uk, and the incidence is rising. the reference standard for diagnosing this condition is prostate biopsy, an invasive procedure. this study systematically reviews recent literature on tpsa accuracy. the time period was restricted to ensure that the estimates referred to contemporary tpsa tests and prostate cancer reference standards. the focus of this review was restricted to european populations as tpsa levels are known to vary by population group. ## Methods: Medline was searched (from 01/1998 to 01/2008) and embase (from 01/1998 to 01/2008), which returned 3087 citations. these were assessed by 6 reviewers, who shortlisted 54 of possible relevance. 2 reviewers assessed each using the following inclusion criteria: data collection between 1998-2008; tpsa measurements for all participants; histological confirmation of the diagnosis; samples from a european population and sufficient data to calculate 2 x 2 tables. the final set of 10 included studies represented 5373 participants. quality of the included studies was assessed in duplicate using criteria suggested by the cochrane collaboration. review manager 5.0 sof

Who reads A Systematic Review of the Diagnostic Accuracy of Prostate Specific Antigen?

Author

Philip Harvey; Amman Basuita; Deborah Endersby; Ben Curtis; Aphrodite Iacovidou; Mary Walker

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2490)

Published

2009

Language

EN

Field

Medicine (Health Sciences)