About this document
Drug Distribution To Human Tissues - Prediction and Examination of The Basic Assumption in in Vivo Pharmacokinetics-Pharmacodynamics Research by opata edward kwame is a document available to read on EtoBox.
This document discusses predicting drug distribution in human tissues using tissue composition-based models. It aims to predict tissue:plasma partition coefficient (Kp) values for specific human tissues and examine relationships between unbound drug fractions in plasma (fup) and tissues (fut) for several drugs. The results indicate the models can accurately predict human Kp values and that fup may deviate significantly from fut due to differences in binding and ionization across membranes.
- Author
- opata edward kwame
- Language
- EN