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Role Of GPR37 In Traumatic Brain Injury-Induced Neuropathic Pain: Distinct Roles Of NPD1 And DHA by Junli Zhao; Haichen Wang; Ru-Rong Ji is a scholarly article available to read on EtoBox.

What is Role Of GPR37 In Traumatic Brain Injury-Induced Neuropathic Pain: Distinct Roles Of NPD1 And DHA about?

GPR37 is an orphan GPCR and expressed in different brain regions. However, its biological function in pain regulation remains poorly understood. Recently, we identified Neuroprotectin D1 (NPD1) as a novel ligand of GPR37. NPD1 is a specialized pro-resolving mediator (SPM) and bio-synthesized from fish oil DHA (docosahexaenoic acid) . Here we reported a protective role of GRP37/NPD1 signaling in traumatic brain injury (TBI)-induced neuropathic pain. Mild TBI was induced by closed-head impact and the neuropathic pain was assessed by periorbital and cutaneous mechanical allodynia. In contrast to DHA (300 μg) showing no effects, peri-surgical treatment of NPD1 via intravenous injection (300 ng) effectively prevented TBI-induced locomotor deficiency and mechanical hypersensitivity in mice. Intraperitoneal post-treatment of NPD1 also significantly reduced established neuropathic pain in TBI mice. We also found that NPD1 treatment could inhibit TBI-induced neuroinflammation, characterized by microglia and astrocyte activation in the cortex and hippocampus. Furthermore, demyelination occurred after TBI, which was prevented by peri-surgical treatment of NPD1. RNAscope in situ hybridization

Author

Junli Zhao; Haichen Wang; Ru-Rong Ji

Publisher

Elsevier BV

Published

2023

Language

EN