Can I read Prospective Assessment of the Hepatic Perfusion Index in Patients with Colorectal Cancer on EtoBox?

Prospective Assessment of the Hepatic Perfusion Index in Patients with Colorectal Cancer by Mr H. W. Warren; H. Gallagher; D. M. Hemingway; W. J. Angerson; R. G. Bessent; H. Wotherspoon; C. S. Mcardle; T. G. Cooke is a scholarly article available to read on EtoBox.

What is Prospective Assessment of the Hepatic Perfusion Index in Patients with Colorectal Cancer about?

## Abstract ## Background This prospective study was designed to test the hypothesis that abnormal liver blood flow is related to poor prognosis in patients with colorectal cancer. ## Methods The hepatic perfusion index (HPI), measured by dynamic hepatic scintigraphy, was assessed in 202 patients with colorectal cancer. Assessment for overt hepatic metastasis included liver palpation at laparotomy and perioperative computed tomography (CT). Follow-up at a dedicated clinic included regular abdominal ultrasonography and CT. ## Results The HPI was abnormal (greater than 0·37) in 92 (88 per cent) of 105 patients with overt liver metastases. Of 89 patients with no evidence of overt metastases or residual tumour after primary resection, 52 had an abnormal and 37 a normal HPI. At a median follow-up of 39 (range 13–76) months, 25 of 38 patients with recurrnce had an abnormal HPI. Some 31 of 45 patients who died had an abnormal HPI. The HPI predicted overall recurrence (P = 0·04, log rank test). Multivariate analysis showed the HPI was independent of Dukes stage for predicting disease-free survival (P = 0·04, relative risk 1·94 (95 per cent confidence interval (c.i.) 1·03–3·67)) but this ju

Author

Mr H. W. Warren; H. Gallagher; D. M. Hemingway; W. J. Angerson; R. G. Bessent; H. Wotherspoon; C. S. Mcardle; T. G. Cooke

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Oxford University Press (OUP) (ISSN 0007-1323)

Published

1998

Language

EN