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Treatment with Ozone/oxygen-pneumoperitoneum Results in Complete Remission of Rabbit Squamous Cell Carcinomas by Siegfried Schulz; Ulrich Häussler; Robert Mandic; Johannes T. Heverhagen; Andreas Neubauer; Anja A. Dünne; Jochen A. Werner; Eberhard Weihe; Michael Bette is a scholarly article available to read on EtoBox.

What is Treatment with Ozone/oxygen-pneumoperitoneum Results in Complete Remission of Rabbit Squamous Cell Carcinomas about?

## Abstract Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells __in vitro__ we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts antitumorous effects __in vivo__. Therapeutic insufflation of medical ozone/oxygen (O~3~/O~2~) gas mixture into the peritoneum (O~3~/O~2~‐pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O~2~) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in 2 of the 3 surviving animals. Of the 14 sham‐treated animals only 1 had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O~3~/O~2~ or O~2~ gas. Animals with O~3~/O~2~‐induced tumor eradication developed tolerance against rei

Author

Siegfried Schulz; Ulrich Häussler; Robert Mandic; Johannes T. Heverhagen; Andreas Neubauer; Anja A. Dünne; Jochen A. Werner; Eberhard Weihe; Michael Bette

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN