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PSA kinetics following IMRT for prostate cancer: the impact of daily stereotactic ultrasound targeting by M Fuss; S Cavanaugh; L Voeltz; C Fuller; B Salter; T Herman is a Medicine article available to read on EtoBox.

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pre-RT PSA level available; the mean PSADT was 8.6 months. No androgen deprivation was delivered at the time of salvage radiotherapy. The median follow-up time was 32 months (range: 1-187). Results: For the entire cohort, the 5 and 7-year bRFS rates after salvage prostate fossa radiotherapy were 54% and 50%, respectively. The 5 and 10-year overall survival rates were 90% and 80%, respectively. The 5 and 10-year clinical disease-free survival rates were 89% and 70%, respectively. On univariate analysis, initial biopsy Gleason score, clinical T-stage, SM status, SV status, and pre-RT PSA were significant predictors of biochemical failure after RT. Age, race, initial PSA level, ECE, LN, PSADT, RT dose, and RT technique were not. The 5-year bRFS rates for patients with negative SM versus positive SM were 42% and 62%, respectively (pϭ0.002). The 5-year bRFS rates for patients with positive SV versus negative SV were 20% and 64%, respectively (pϽ0.001). The 5-year bRFS rates for patients with a preRT PSA Յ1.0 versus Ͼ1.0 were 58% and 37%, respectively (pϭ0.079). On multivariate analysis, SM status, SV status, and pre-RT PSA (continuous variable) were the only significant predictors of fa

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Author

M Fuss; S Cavanaugh; L Voeltz; C Fuller; B Salter; T Herman

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2003

Language

EN

Field

Medicine (Health Sciences)