Opening book details…
Can I read Dealing with the Unknown: Metabolomics and Metabolite Atlases on EtoBox?
Dealing with the Unknown: Metabolomics and Metabolite Atlases by Benjamin P. Bowen; Trent R. Northen is a Chemistry article available to read on EtoBox.
What is Dealing with the Unknown: Metabolomics and Metabolite Atlases about?
Metabolomics is the comprehensive profiling of the small molecule composition of a biological sample. Since metabolites are often the indirect products of gene expression, this approach is being used to provide new insights into a variety of biological systems (clinical, bioenergy, etc.). A grand challenge for metabolomics is the complexity of the data, which often include many experimental artifacts. This is compounded by the tremendous chemical diversity of metabolites. Identification of each uncharacterized metabolite is in many ways its own puzzle (compared with proteomics, which is based on predictable fragmentation patterns of polypeptides). Therefore, effective data reduction/prioritization strategies are critical for this rapidly developing field. Here we review liquid chromatography electrospray ionization mass spectrometry (LC/MS)-based metabolomics, methods for feature finding/prioritization, approaches for identifying unknown metabolites, and construction of method specific 'Metabolite Atlases'.
Who reads Dealing with the Unknown: Metabolomics and Metabolite Atlases?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Benjamin P. Bowen; Trent R. Northen
- Publisher
- Elsevier Science; Springer-Verlag; Springer New York LLC; American Chemical Society (ACS); Springer Science and Business Media LLC; Elsevier BV (ISSN 1044-0305)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)