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Insulin Secretion Decline Unrelated to Jejunal Morphology or Exocrine Pancreatic Function in Children with Celiac Disease by Thomais Karagiozoglou-Lampoudi; Sanda Nousia-Arvanitaki; Persa Augoustidou-Savopoulou; Nikos Salem; Zaharias Polymenidis; Florence Kanakoudi-Tsakalidou is a scholarly article available to read on EtoBox.

What is Insulin Secretion Decline Unrelated to Jejunal Morphology or Exocrine Pancreatic Function in Children with Celiac Disease about?

We describe a prospective 10-year study of insulin secretion and immunologic changes in a group of children with celiac disease (CD) on a gluten-free diet. Thirty CD patients aged 4-16 years and 30 matched controls were examined. They underwent i.v. glucose tolerance test during which glucose disappearance rate (K) and first phase insulin response (FPIR) were measured. Typing for HLA A, B, C, and DR antigens was performed and sera were analyzed for cytoplasmic islet cell antibodies (ICA) on several occasions. Pancreatic isoamylase (PIA) was measured to assess exocrine pancreatic function. In 4/21 CD children, FPIR and Κ rate were decreased. There was a significant correlation between the two parameters (p<0.01). The incidence of HLA B 8 and DR3 was higher in CD (33% and 60%, respectively) than in healthy individuals (p<0.001). All patients were found to be ICA negative at the time of the study and at follow-up. There was no correlation between

Author

Thomais Karagiozoglou-Lampoudi; Sanda Nousia-Arvanitaki; Persa Augoustidou-Savopoulou; Nikos Salem; Zaharias Polymenidis; Florence Kanakoudi-Tsakalidou

Published

1996

Language

EN