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Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG) by Scott T. Miller; Winfred C. Wang; Rathi Iyer; Sohail Rana; Peter Lane; Russell E. Ware; Daner Li; Renée C. Rees is a Medicine article available to read on EtoBox.

What is Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG) about?

## Abstract ## Background A urine concentrating defect is quite common in sickle cell anemia, has its onset in early childhood, and may be reversible with transfusion. The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) is a double‐blind, placebo‐controlled trial to assess efficacy of hydroxyurea in preventing organ damage in young children with sickle cell anemia. ## Procedures Enrolled infants were subjected to parent‐supervised fluid deprivation, and urine and serum osmolality were determined. ## Results Of 185 infants age 7.5–17.9 months (mean 13.0 ± 2.7) and fluid‐deprived 7.4 ± 2.4 hr (range 4–13), 178 had concurrent determinations of urine and serum osmolality. Mean serum osmolality was 286 ± 6 mOsm/kg H~2~O (range 275–312) and independent of age, height, weight, or duration of fluid deprivation. Urine osmolality (mean 407 ± 151, range 58–794 mOsm/kg H~2~O) was greater than serum (__P__ 500 mOsm/kg H~2~O. Urine osmolality correlated with ^99m^Tc‐DTPA clearance (__P__ = 0.02) and serum urea nitrogen (__P__ 500 mOsm/kg H~2~O had higher mean fetal hemoglobin concentrations than did those who could not (__P__ = 0.014). ## Conclusions Even with often limited fluid dep

Who reads Urine concentrating ability in infants with sickle cell disease: Baseline data from the phase III trial of hydroxyurea (BABY HUG)?

Author

Scott T. Miller; Winfred C. Wang; Rathi Iyer; Sohail Rana; Peter Lane; Russell E. Ware; Daner Li; Renée C. Rees

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2009

Language

EN

Field

Medicine (Health Sciences)