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Yeast 14-3-3 Proteins by G. Paul H. van Heusden; H. Yde Steensma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract 14‐3‐3 proteins form a family of highly conserved proteins which are present in all eukaryotic organisms investigated, often in multiple isoforms, up to 13 in some plants. They interact with more than 200 different, mostly phosphorylated proteins. The molecular consequences of 14‐3‐3 binding are diverse: this binding may result in stabilization of the active or inactive phosphorylated form of the protein, to a conformational alteration leading to activation or inhibition, to a different subcellular localization, to the interaction with other proteins or to shielding of binding sites. The binding partners, and hence the 14‐3‐3 proteins, are involved in almost every cellular process and 14‐3‐3 proteins have been linked to several diseases, such as cancer, Alzheimer's disease, the neurological Miller–Dieker and spinocerebellar ataxia type 1 diseases and bovine spongiform encephalopathy (BSE). The yeasts __Saccharomyces cerevisiae__ and __Schizosaccharomyces pombe__ both have two genes encoding 14‐3‐3 proteins, __BMH1__ and __BMH2__ and __rad24__ and __rad25__, respectively. In these yeasts, 14‐3‐3 proteins are essential in most laboratory strains. As in higher eukaryotes,

Who reads Yeast 14-3-3 Proteins?

Author

G. Paul H. van Heusden; H. Yde Steensma

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)