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Maspin Is Up-regulated in Premalignant Prostate Epithelia by Christopher R. Pierson; Richard McGowen; David Grignon; Wael Sakr; Jyotirmoy Dey; Shijie Sheng is a Medicine article available to read on EtoBox.

What is Maspin Is Up-regulated in Premalignant Prostate Epithelia about?

## Abstract ## BACKGROUND Maspin, a novel serine protease inhibitor, has been shown to inhibit prostate tumor cell motility and invasion in vitro and to inhibit prostate tumor growth and metastasis in vivo. Maspin expression in high‐grade prostate carcinoma (PC) is reduced compared with that in low‐grade PC. Interestingly, however, compared with low‐grade PC, benign secretory prostate epithelial cells express significantly less maspin. This observation appears paradoxical to a putative tumor suppressive role of maspin in prostate carcinogenesis, and this finding issue needs to be clarified. ## METHODS We examined maspin expression simultaneously in benign basal cells, benign secretory cells, high‐grade prostate intraepithelial neoplasia (HGPIN), low‐grade PC, and high‐grade PC in 46 radical prostatectomy specimens plus 51 autopsy prostate glands by a combination of immunohistochemistry and in situ hybridization. ## RESULTS Benign basal cells consistently expressed maspin at a high level. In PC, the loss of basolateral maspin expression coincides with loss of the basal cell layer. Maspin expression in secretory cells, on the other hand, appears to undergo a biphasic differential reg

Who reads Maspin Is Up-regulated in Premalignant Prostate Epithelia?

Author

Christopher R. Pierson; Richard McGowen; David Grignon; Wael Sakr; Jyotirmoy Dey; Shijie Sheng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2002

Language

EN

Field

Medicine (Health Sciences)