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What is Acute Hypotensive Transfusion Reactions about?

This document summarizes acute hypotensive transfusion reactions (AHTRs), which are characterized by an abrupt onset of hypotension as the primary clinical manifestation when a blood transfusion is stopped. The pathophysiology involves disturbances in the production and metabolism of bradykinin, a vasoactive peptide. Recognition of AHTRs has increased due to greater use of ACE inhibitors and leukoreduction filters, both of which can alter bradykinin kinetics. The review describes the epidemiology of AHTRs,

Author

Taufik Karami

Language

EN