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Rapid Hemostasis and Excellent Antibacterial Cerium-containing Mesoporous Bioactive Glass/chitosan Composite Sponge for Hemostatic Material by Jiaxi Liu; Xiang Zhou; Yin Zhang; Wei Zhu; Anping Wang; Meijia Xu; Shuxian Zhuang is a scholarly article available to read on EtoBox.

What is Rapid Hemostasis and Excellent Antibacterial Cerium-containing Mesoporous Bioactive Glass/chitosan Composite Sponge for Hemostatic Material about?

Rapid and effective hemostasis is key to controlling bleeding and reducing mortality. Here, a composite hemostatic sponge (Ce-MBG/CHT) of cerium-containing mesoporous bioactive glass (Ce-MBG) and chitosan (CHT) was prepared by a freeze-drying technique and compared with the commercially available gelatin sponge (GS), to further evaluate the hemostatic performance of composite sponge materials. The results indicate that the pore structure, porosity, and water absorption of the sponge improved following the addition of Ce-MBG. Whole blood coagulation studies suggested that Ce-MBG/CHT has superior hemostatic properties to GS and validated in vitro thrombosis, platelet adhesion and blood compatibility. In vitro coagulation studies showed that factor XII was activated by the addition of Ce-MBG, inducing the intrinsic coagulation pathway. Furthermore, we evaluated the cytocompatibility of samples after contact with L929 cells for 24, 48, and 72 h via the cytotoxicity test. Compared with GS, 4Ce-MBG/CHT was more efficient against E. coli and S. aureus. All these results indicate that Ce-MBG/CHT sponges are likely useful for rapid hemostasis.

Author

Jiaxi Liu; Xiang Zhou; Yin Zhang; Wei Zhu; Anping Wang; Meijia Xu; Shuxian Zhuang

Publisher

Elsevier BV

Published

2022

Language

EN