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Effects of Myocardial Function and Systemic Circulation on Regional Coronary Perfusion by Ravi Namani; Lik C. Lee; Yoram Lanir; Benjamin Kaimovitz; Sheikh M. Shavik; Ghassan S. Kassab is a Medicine article available to read on EtoBox.

What is Effects of Myocardial Function and Systemic Circulation on Regional Coronary Perfusion about?

Cardiac-coronary interaction and the effects of its pathophysiological variations on spatial heterogeneity of coronary perfusion and myocardial work are still poorly understood. This hypothesis-generating study predicts spatial heterogeneities in both regional cardiac work and perfusion that offer a new paradigm on the vulnerability of the subendocardium to ischemia, particularly at the apex. We propose a mathematical and computational modeling framework to simulate the interaction of left ventricular mechanics, systemic circulation, and coronary microcirculation. The computational simulations revealed that the relaxation rate of the myocardium has a significant effect whereas the contractility has a marginal effect on both the magnitude and transmural distribution of coronary perfusion. The ratio of subendocardial to subepicardial perfusion density () changed by -12 to +6% from a baseline value of 1.16 when myocardial contractility was varied by +25 and -10%, respectively; changed by 37% when sarcomere relaxation rate, , was faster and increased by 10% from the baseline value. The model predicts axial differences in regional myocardial work and perfusion density across the wall th

Who reads Effects of Myocardial Function and Systemic Circulation on Regional Coronary Perfusion?

Author

Ravi Namani; Lik C. Lee; Yoram Lanir; Benjamin Kaimovitz; Sheikh M. Shavik; Ghassan S. Kassab

Publisher

The American Physiological Society; American Physiological Society (ISSN 8750-7587)

Published

2020

Language

EN

Field

Medicine (Health Sciences)