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Epigenetic Modifications in the Embryonic and Induced Pluripotent Stem Cells by Rasoul Godini; Haider Yabr Lafta; Hossein Fallahi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Epigenetic Modifications in the Embryonic and Induced Pluripotent Stem Cells about?

Epigenetic modifications are involved in global reprogramming of the cell transcriptome. Therefore, synchronized major shifts in the expression of many genes could be achieved through epigenetic changes. The regulation of gene expression could be implemented by different epigenetic events including histone modifications, DNA methylation and chromatin remodelling. Interestingly, it has been documented that reprogramming of somatic cells to induced pluripotent stem (iPS) cells is also a typical example of epigenetic modifications. Additionally, epigenetic would determine the fates of almost all cells upon differentiation of stem cells into somatic cells. Currently, generation of iPS cells through epigenetic modifications is a routine laboratory practice. Despite all our knowledge, inconsistency in the results of reprogramming and differentiation of stem cells, highlight the need for more thorough investigation into the role of epigenetic modification in generation and maintenance of stem cells. Besides, subtle differences have been observed among different iPS cells and between iPS and ES cells. Although, a handful of detailed review regarding the status of epigenetics in stem cells

Who reads Epigenetic Modifications in the Embryonic and Induced Pluripotent Stem Cells?

Author

Rasoul Godini; Haider Yabr Lafta; Hossein Fallahi

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)