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Recent Advances of pH‐Induced Charge‐Convertible Polymer‐Mediated Inorganic Nanoparticles for Biomedical Applications by Hong Yu Yang; Yi Li; Doo Sung Lee is a Materials Science article available to read on EtoBox.

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## Abstract The incorporation of functional polymers and inorganic nanoparticles into nanoplatforms has the potential to produce personalized nanomedicine systems for further biomedical applications. Polymers that endow inorganic nanoparticles with unique surface properties for prolonged blood circulation and improved tumor targeting and cellular uptake are especially desired. pH‐induced charge‐switchable polymers are sensitive to the pH of the tumor environment and maintain a negative or neutral charge in blood circulation, increasing their circulation time and enhancing tumor accumulation via the enhanced permeability and retention effect. This type of polymer further transforms its charge to positive in acidic tumor locations to promote cellular uptake. Furthermore, the combination of pH‐induced charge‐switchable polymers with various inorganic nanoparticles (e.g., magnetic nanoparticles, gold nanoparticles, quantum dots, and upconversion materials) activates their intrinsic functions in in situ diagnosis and disease therapy. This review briefly overviews the recent progress in the development and application of various pH‐induced charge‐convertible polymers functionalized with

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Author

Hong Yu Yang; Yi Li; Doo Sung Lee

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1022-1336)

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)