Can I read Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage on EtoBox?

Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage by Philippe Colson; Anthony Levasseur; Jeremy Delerce; Lucile Pinault; Pierre Dudouet; Christian Devaux; Pierre-Edouard Fournier; Bernard La Scola; Jean-Christophe Lagier; Didier Raoult is a Medicine article available to read on EtoBox.

What is Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage about?

## Objectives: Surveillance of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) genomic epidemiology led us to detect several variants since summer 2020. we report the recent spread of a new sars-cov-2 spike 501y variant. ## Methods: Sars-cov-2 sequences obtained from human nasopharyngeal samples by illumina next-generation sequencing were analysed using nextclade and an in-house python script and were compared using blastn to the gisaid database. phylogeny was investigated using the iq-tree software. ## Results: We identified that sars-cov-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including l18f, l452r, n501y, a653v, h655y, d796y, g1219v ± q677h. these spike n501y genomes are the first of nextstrain clade 19b. we obtained partial spike gene sequences of this genotype for an additional 43 patients. all patients infected with this genotype were diagnosed since mid-january 2021. we detected 42 other genomes of this genotype in gisaid, which were obtained from samples collected in december 2020 in four individuals and in 2021 in 38 individuals. the 89 sequences obtained in our institute or other laboratories ori

Who reads Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage?

Author

Philippe Colson; Anthony Levasseur; Jeremy Delerce; Lucile Pinault; Pierre Dudouet; Christian Devaux; Pierre-Edouard Fournier; Bernard La Scola; Jean-Christophe Lagier; Didier Raoult

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)