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P: 64 Multimodal Approach Including MR-spectroscopy for the Diagnosis of Minimal Hepatic Encephalopathy by Weiss, Nicolas; Hermann, Bertrand; Rudler, Marika; Bouzbib, Charlotte; Galanaud, Damien; Mallet, Maxime; Duvoux, Christophe; Coilly, Audrey; Francoz, Claire; Plessier, Aurélie; Thabut, Dominique is a Medicine article available to read on EtoBox.
What is P: 64 Multimodal Approach Including MR-spectroscopy for the Diagnosis of Minimal Hepatic Encephalopathy about?
BACKGROUND: To determine the impact of genetic factors on the development of hepatic encephalopathy (HE) in patients with liver cirrhosis. METHODS: Patients suffering from compensated liver cirrhosis [n 5 434; estimation cohort (n 5 294) and validation cohort (n 5 140)] were included. Patients were followed up for five years until HE bouts, liver transplant, or death. Methods: Patients were genotyped for 62 candidate SNPs (genes involved in the pathophysiology of HE: inflammation, ammonia and glutamine metabolism, intestinal barrier integrity and oxidative stress) by using OpenArray custom plates. Likewise, a haplotype formed by four SNPs within GLS plus the length of a microsatellite in the promoter region of GLS were determined (Romero-Gómez et al. Ann Intern Med 2010). Statistical analysis was performed by Cox regression and Kaplan-Meier for continuous and categorical data. Significant variables, and those known as weighted prognostic indicators, were entered into multivariable models by competing risks, according to Fine and Gray's method. RESULTS: In the estimation cohort, competing risks analysis showed GLS mutations, FUT2-(rs601338), TLR9-(rs5743836), SLC1A3-(rs2562582) and
Who reads P: 64 Multimodal Approach Including MR-spectroscopy for the Diagnosis of Minimal Hepatic Encephalopathy?
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- Author
- Weiss, Nicolas; Hermann, Bertrand; Rudler, Marika; Bouzbib, Charlotte; Galanaud, Damien; Mallet, Maxime; Duvoux, Christophe; Coilly, Audrey; Francoz, Claire; Plessier, Aurélie; Thabut, Dominique
- Publisher
- Nature Publishing Group; American College of Gastroenterology; Springer Verlag; Ovid Technologies (Wolters Kluwer Health); Springer Science and Business Media LLC; Wiley (ISSN 0002-9270)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)