Can I read Electroshocks Delay Seizures and Subsequent Epileptogenesis but Do Not Prevent Neuronal Damage in the Lithium–pilocarpine Model of Epilepsy on EtoBox?

Electroshocks Delay Seizures and Subsequent Epileptogenesis but Do Not Prevent Neuronal Damage in the Lithium–pilocarpine Model of Epilepsy by Véronique André; Arielle Ferrandon; Christian Marescaux; Astrid Nehlig is a Medicine article available to read on EtoBox.

What is Electroshocks Delay Seizures and Subsequent Epileptogenesis but Do Not Prevent Neuronal Damage in the Lithium–pilocarpine Model of Epilepsy about?

Electroconvulsive therapy, which is used to treat refractory major depression in humans increases seizure threshold and decreases seizure duration. Moreover, the expression of brain derived neurotrophic factor induced by electroshocks (ECS) might protect hippocampal cells from death in patients suffering from depression. As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat. Eleven maximal ECS were applied via ear-clips to adult rats. The last one was applied 2 days before the induction of SE by lithium-pilocarpine. The rats were electroencephalographically recorded to study the SE characteristics. The rats treated with ECS before pilocarpine (ECS-pilo) developed partial limbic (score 2) and propagated seizures (score 5) with a longer latency than the rats that underwent SE alone (sham-pilo). Despite this delay in the initiation and propagation of the seizures, the same number of ECS-and sham-pilo rats developed SE with a similar characteristic pattern. The expression of c-Fos protein was down-regul

Who reads Electroshocks Delay Seizures and Subsequent Epileptogenesis but Do Not Prevent Neuronal Damage in the Lithium–pilocarpine Model of Epilepsy?

Author

Véronique André; Arielle Ferrandon; Christian Marescaux; Astrid Nehlig

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2000

Language

EN

Field

Medicine (Health Sciences)