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In Vivo Sodium Chemical Shift Imaging by Susan. J. Kohler; Nancy H. Kolodny; Ann C. Celi; Tracey A. Burr; David Weinberg; Donald J. D'amico; Evangelos S. Gragoudas is a Medicine article available to read on EtoBox.

What is In Vivo Sodium Chemical Shift Imaging about?

## Abstract The shift reagents thulium(III) 1,4,7,10‐tetraazacyclododecane __N__, N′, N′′, N′′′ tetramethylenephosphonate (TmDOTPS^5−^), and dysprosium(III) triethylenetetraminehexaacetate (DyTTHA^3−^) are compared in this work for their uses in sodium chemical shift imaging (NaCSI). In a series of experiments using phantoms we evaluated the relative contributions of bulk magnetic susceptibility (BMS) effects and hyperfine shifts to the induced ^23^Na chemical shift for these two shift reagents. The ratios of BMS effects to hyperfine shifts suggest that TmDOTP^5−^ should be a more effective shift reagent than DyTTHA^3−^ for ^23^Na NMR spectroscopy as well as NaCSI. The dependence on pH and free Ca^2+^ concentration of the ^23^Na NMR frequency shift induced by TmDOTP^5−^ was evaluated. It was found that TmDOTP^5−^ produces good spectral resolution under physiologic conditions. Examples presented from __in vivo__ NaCSI experiments using TmDOTP^5−^ to study diffusion in the posterior chamber of the rabbit eye and to monitor the rate of clearance of aqueous fluid from the anterior chamber demonstrate the effectiveness of this new shift reagent and of the NaCSI technique for __in vivo__

Who reads In Vivo Sodium Chemical Shift Imaging?

Author

Susan. J. Kohler; Nancy H. Kolodny; Ann C. Celi; Tracey A. Burr; David Weinberg; Donald J. D'amico; Evangelos S. Gragoudas

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

1992

Language

EN

Field

Medicine (Health Sciences)