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Role of Consolidative Thoracic Radiation in Extensive-stage Small-cell Lung Cancer with First-line Chemoimmunotherapy: a Retrospective Study from a Single Cancer Center by Yuying Li; Wang Jing; Xuquan Jing; Yulan Sun; Xiaoyong Tang; Jun Guo; Yan Zhang; Hui Zhu is a Medicine article available to read on EtoBox.

What is Role of Consolidative Thoracic Radiation in Extensive-stage Small-cell Lung Cancer with First-line Chemoimmunotherapy: a Retrospective Study from a Single Cancer Center about?

## Objective To investigate the role of consolidative thoracic radiation (TRT) in extensive-stage small-cell lung cancer (ES-SCLC) receiving first-line chemo-immunotherapy followed by immunotherapy maintenance. ## Patients and methods Outcomes of patients without disease progression after first-line chemotherapy were retrospectively reviewed (January 2020 to December 2021). Based on TRT or not, patients were allocated to TRT group or non-TRT group. Progression-free survival (PFS), overall survival (OS) and local-recurrence free survival (LRFS) were calculated by the Kaplan–Meier method and compared by log-rank test. ## Results Of 100 patients, 47 received TRT and 53 non-TRT. The median follow-up was 20.3 months. The median PFS and OS in TRT were 9.1 months and 21.8 months, versus 8.8 months (__p__ = 0.93) and 24.3 months (__p__ = 0.63), respectively, in non-TRT. The median LRFS time in TRT was not reached, but significantly longer than 10.8 months in non-TRT (HR = 0.27, __p__ < 0.01). Second-line chemotherapy significantly prolonged survival compared to that with chemo-free patients (mOS: 24.5 vs. 21.4 months, __p__ = 0.026). The subgroup analysis showed a trend of patients with br

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Author

Yuying Li; Wang Jing; Xuquan Jing; Yulan Sun; Xiaoyong Tang; Jun Guo; Yan Zhang; Hui Zhu

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)