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3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration by Yongcong Fang; Chengjin Wang; Zibo Liu; Jeonghoon Ko; Li Chen; Ting Zhang; Zhuo Xiong; Lei Zhang; Wei Sun is a Engineering article available to read on EtoBox.

## Abstract Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs. In this study, a conductive multiscale filled NGC (MF‐NGC) consisting of electrospun poly(lactide‐co‐caprolactone) (PCL)/collagen nanofibers as the sheath, reduced graphene oxide /PCL microfibers as the backbone, and PCL microfibers as the internal structure for peripheral nerve regeneration is developed. The printed MF‐NGCs presented good permeability, mechanical stability, and electrical conductivity, which further promoted the elongation and growth of Schwann cells and neurite outgrowth of PC12 neuronal cells. Animal studies using a rat sciatic nerve injury model reveal that the MF‐NGCs promote neovascularization and M2 transition through the rapid recruitment of vascular cells and macrophages. Histological and functional assessments of the regenerated nerves confirm that the conductive MF‐NGCs significantly enhance peripheral nerve regeneration, as indicated by improved axon myelination, muscle weight increase, and scia

Author

Yongcong Fang; Chengjin Wang; Zibo Liu; Jeonghoon Ko; Li Chen; Ting Zhang; Zhuo Xiong; Lei Zhang; Wei Sun

Publisher

Wiley

Published

2023

Language

EN

Field

Engineering (Physical Sciences)