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The Chylomicronemia Syndrome Is Most Often Multifactorial: A Narrative Review of Causes and Treatment by Alan Chait; Robert H. Eckel is a Medicine article available to read on EtoBox.
What is The Chylomicronemia Syndrome Is Most Often Multifactorial: A Narrative Review of Causes and Treatment about?
The chylomicronemia syndrome occurs when triglyceride levels are severely elevated (usually >16.95 mmol/L [1500 mg/dL]) and is characterized by such clinical features as abdominal pain, acute pancreatitis, eruptive xanthomas, and lipemia retinalis. It may result from 1 of 3 conditions: the presence of secondary forms of hypertriglyceridemia concurrent with genetic causes of hypertriglyceridemia, termed multifactorial chylomicronemia syndrome (MFCS); a deficiency in the enzyme lipoprotein lipase and some associated proteins, termed familial chylomicronemia syndrome (FCS); or familial partial lipodystrophy. Most chylomicronemia syndrome cases are the result of MFCS; FCS is very rare. In all these conditions, triglyceride-rich lipoproteins accumulate because of impaired plasma clearance. This review describes the 3 major causes of the chylomicronemia syndrome; their consequences; and the approaches to treatment, which differ considerably by group.
Who reads The Chylomicronemia Syndrome Is Most Often Multifactorial: A Narrative Review of Causes and Treatment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alan Chait; Robert H. Eckel
- Publisher
- American College of Physicians (ISSN 0003-4819)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)