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Metrological properties of neuropsychological tests for measuring cognitive change in individuals with prodromal Alzheimer’s disease by Xinnan Zhang; Yan Wu; Yao He; Xiaoyan Ge; Jing Cui; Hongjuan Han; Yanhong Luo; Long Liu; Zhixin Wang; Hongmei Yu; the Alzheimer’s Disease Neuroimaging Initiative is a Psychology article available to read on EtoBox.
What is Metrological properties of neuropsychological tests for measuring cognitive change in individuals with prodromal Alzheimer’s disease about?
## Objectives: In alzheimer's disease (ad) research, choosing appropriate method for measuring change in cognitive function over time can be challenging. the aim for this study was to examine the sensitivity of four neuropsychological tests used to measure cognition during the transition from mild cognitive impairment (mci) to ad, and the impacts of associated covariates. ## Methods: We enrolled 223 patients with mci who progressed to ad and had completed multiple follow-up assessments in the alzheimer's disease neuroimaging initiative (adni) database. we constructed nonlinear mixed model for multivariate longitudinal data assuming that multiple neuropsychological tests would exhibit nonlinear transformation of a common factor in the latent cognitive process underlying the progression from mci to ad. ## Results: The clinical dementia rating-sum of the boxes (cdr-sb) and alzheimer's disease assessment scale (11 items; adas-11) were more sensitive to cognitive changes in individuals with higher cognitive function, the functional activities questionnaire (faq) was more sensitive to cognitive changes in individuals with middle cognitive function, and the mini-mental state examination (
Who reads Metrological properties of neuropsychological tests for measuring cognitive change in individuals with prodromal Alzheimer’s disease?
It is typically read by researchers, students, and practitioners in Psychology.
- Author
- Xinnan Zhang; Yan Wu; Yao He; Xiaoyan Ge; Jing Cui; Hongjuan Han; Yanhong Luo; Long Liu; Zhixin Wang; Hongmei Yu; the Alzheimer’s Disease Neuroimaging Initiative
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Psychology (Social Sciences)