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PolyQ Proteins Disrupt Protein Degradation by Võ Đức Duy is a document available to read on EtoBox.
PolyQ-expanded proteins disrupt the clearance of misfolded cytosolic proteins by sequestering the essential chaperone Sis1p, which is crucial for their nuclear transport for proteasomal degradation. This study demonstrates that polyQ aggregation impairs the ubiquitin-proteasome system (UPS) without blocking ubiquitylation or proteasome function, leading to the accumulation of misfolded proteins and cytoplasmic inclusions. The findings highlight the role of Sis1p in maintaining proteostasis and suggest that
- Author
- Võ Đức Duy
- Language
- EN