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Can I read H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis on EtoBox?
H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis by Rossella Cannarella; Andrea Crafa; Federica Barbagallo; Scott D. Lundy; Sandro La Vignera; Rosita A. Condorelli; Aldo E. Calogero is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis about?
This systematic review and meta-analysis summarize the difference in the methylation of the __H19__ gene in patients with abnormal versus normal conventional sperm parameters. It also evaluates the effects of age and sperm concentration on __H19__ methylation in spermatozoa using meta-regression analysis. It was performed according to the MOOSE guidelines for meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The quality of the evidence reported in the studies included was assessed using the Cambridge Quality Checklists. A total of 11 articles met our inclusion criteria. Quantitative analysis showed that __H19__ methylation levels were significantly lower in the group of infertile patients than in fertile controls. The reduction in methylation was much more pronounced in patients with oligozoospermia (alone or associated with other sperm parameter abnormalities) and in those with recurrent pregnancy loss. Meta-regression analysis showed the results to be independent of both patient age and sperm concentration. Therefore, the __H19__ methylation pattern should be evaluated amon
Who reads H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rossella Cannarella; Andrea Crafa; Federica Barbagallo; Scott D. Lundy; Sandro La Vignera; Rosita A. Condorelli; Aldo E. Calogero
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)