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Resolution of Alcoholic Neuropathy Following Liver Transplantation by Edward Gane; Rachael Bergman; David Hutchinson is a Medicine article available to read on EtoBox.

What is Resolution of Alcoholic Neuropathy Following Liver Transplantation about?

Between 10 and 20% of adult liver transplants are performed for end-stage alcoholic liver disease. Severe extrahepatic end-organ damage from alcoholism (cardiomyopathy, pancreatitis, central nervous system injury, and neuropathy) is widely regarded as an absolute contraindication to liver transplantation, despite a lack of data on the effect of transplantation on these complications. We describe such a patient who presented with decompensated alcoholic liver disease and moderately severe peripheral neuropathy. Both his liver failure and neuropathy progressed despite 9 months abstinence and intensive nutritional support. By 12 months post-transplant, however, this patient had regained almost normal muscle strength, with associated recovery in sensory and motor conduction velocities. Direct alcohol toxicity, nutritional and vitamin deficiencies, and liver failure were all likely etiologic factors in this patient's neuropathy. In conclusion, this case suggests that peripheral neuropathy in a patient with alcoholic cirrhosis may resolve following liver transplantation and should not constitute a contraindication to transplantation, even when it is disabling.

Who reads Resolution of Alcoholic Neuropathy Following Liver Transplantation?

Author

Edward Gane; Rachael Bergman; David Hutchinson

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2004

Language

EN

Field

Medicine (Health Sciences)